鏈潵5骞存渶鐣呴攢鐨勬姉鑲跨槫鑽墿

椴佸崡鍒惰嵂闆嗗洟 2017-06-09 14:57:45
灞变笢


鎹€婄編鍥藉尰瀛︿細鏉傚織銆嬫姤閬擄紝2013骞村叏鐞冪檶鐥囨偅鑰呯害涓?540涓囥€傚叾涓紝鍙戝睍涓浗瀹剁殑鐧岀棁姝讳骸鐜囬珮浜庡彂杈惧浗瀹讹紝鎮g梾浜烘暟鍗犲埌鍏ㄧ悆鐨?7%锛屾浜′汉鏁伴珮杈惧叏鐞冪殑65%銆?013骞翠腑鍥界檶鐥囧彂鐥呬緥鏁颁负308涓囷紝鍗犲叏鐞冪檶鐥囧勾鍙戠梾鏁扮殑20.7%锛屽苟涓旀偅鐥呬汉鏁颁粛鍦ㄥ鍔犮€傞壌浜庤偪鐦ゆ不鐤楃殑澶嶆潅鎬т笌浜轰滑鐨勯渶姹傦紝鎶楄偪鐦よ嵂鐗╃殑甯傚満鍓嶆櫙骞块様銆侟/span>


鏈€鍒濈殑鎶楄偪鐦よ嵂鐗╁涓哄皬鍒嗗瓙鍖栧悎鐗╋紝鑷粠鍑虹幇鍗曞厠闅嗘姉浣撹嵂鐗╀箣鍚庯紝鎶楄偪鐦よ嵂鐗╅攢鍞鍓嶅嚑鍚嶉€愭笎琚叾鍙栦唬銆傞姘磋疆娴佽浆锛屽埌2022骞达紝鐩墠閿€鍞壇濂界殑鑽墿灏嗗湪姒滃崟鍓嶅嚑鍚嶄腑娑堝け銆傛嵁Quintiles IMS鍏徃鍒嗘瀽锛屽埌2022骞达紝棰勮鍓?5鍚嶆姉鑲跨槫鑽墿鐨勯攢鍞灏嗚揪鍒?00浜跨編鍏冦€傝繖涓€鏁板瓧灏嗘槸鐜板湪缇庡浗鍒惰嵂甯傚満鐨勫洓鍒嗕箣涓€锛屾瘮鏃ユ湰鎴栦腑鍥界殑鏁翠釜鍒惰嵂琛屼笟杩樿澶с€傚湪鏈潵5骞翠腑锛屽墠10鐣呴攢鑽搧涓皢浼氭湁3绉峆D-1 / PD-L1鎴栨鏌ョ偣鎶戝埗鍓傜被鑽墿銆傝繖绉嶅叏鏂扮殑鎶楄偪鐦よ嵂鐗╅€氳繃婵€娲诲厤鐤郴缁燂紝浣垮叾鑳藉璇嗗埆鐧岀粏鑳炲苟娑堢伃瀹冧滑锛岃繖绫昏嵂鐗╁湪鐧岀棁鐨勬不鐤椾腑鍙栧緱浜嗗墠鎵€鏈湁鐨勫姛鏁堛€侟/span>



鍗充娇鑲跨槫鍏嶇柅娌荤枟鑽墿涓婂崌锛屽湪2022骞寸晠閿€鐨?0绉嶈嵂鐗╀腑澶у鏁颁粛鐒舵槸鍗曞厠闅嗘姉浣撹嵂鐗╋紝浣嗘槸瀹冧滑鐨勭姸鍐靛嵈涓嶅涔愯锛屾湭鏉ュ嚑骞村唴灏嗛潰涓寸敓鐗╃被浼艰嵂鐨勭珵浜夈€侟/span>

1銆?/span>Revlimid

Revlimid(閫氱敤鍚嶏細鏉ラ偅搴﹁兒)鏄編鍥芥柊鍩哄叕鍙稿紑鍙戠殑鍖栧鑽紝鐩墠閿€鍞涓?0浜跨編鍏冿紝棰勮鍒?022骞磋揪鍒?50浜跨編鍏冿紝鎴愪负鏈€鐣呴攢鐨勬姉鑲跨槫鑽紝鍙Revlimid鐨勫闀挎綔鍔涘法澶с€?005骞磋幏FDA鎵瑰噯涓婂競锛岀敤浜庢不鐤楅楂撳鐢熷紓甯哥患鍚堝緛(MDS)锛?006骞达紝FDA鎵瑰噯浜嗘潵閭e害鑳虹殑涓€涓柊閫傚簲鐥囷紝鍗冲悎鐢ㄥ湴濉炵背鏉?Dexamethasone)娌荤枟宸茬粡鎺ュ彈杩囪嚦灏戜竴绉嶇枟娉曠殑澶氬彂鎬ч楂撶槫鎮h€咃紱2013骞达紝FDA鎵瑰噯鏉ラ偅搴﹁兒鐢ㄤ簬娌荤枟缁?绉嶈嵂鐗?鍏朵腑涓€绉嶄负纭兼浛浣愮背)娌荤枟鍚庝粛鐒跺鍙戞垨杩涘睍鐨勫缁嗚優娣嬪反鐦?MCL)鎮h€呯殑琛ュ厖鏂拌嵂鐢宠銆傞璁¤鑽墿鍒?022骞寸殑澶嶅悎骞村闀块璁″皢閮ㄥ垎鏉ヨ嚜鏂扮殑閫傚簲鐥囷紝濡傛护娉℃€ф穻宸寸槫鍜岄潪闇嶅閲戞穻宸寸槫(NHL)銆傛穻宸寸槫灏嗗湪2020骞村強浠ュ悗鎴愪负涓昏鐨勫闀块┍鍔ㄥ姏銆侟/span>

2銆?/span>Opdivo

鐧炬椂缇庢柦璐靛疂鍏徃鐨凮pdivo鏄涓狿D-1 / PD-L1鎶戝埗鍓傜被鑽墿骞跺湪鏃ユ湰涓婂競锛?014骞?2鏈堬紝缇庡浗FDA鍔犻€熸壒鍑哋pdivo鐢ㄤ簬娌荤枟鏃犳硶鎵嬫湳鍒囬櫎鎴栧凡缁忓嚭鐜拌浆绉讳笖瀵瑰叾瀹冭嵂鐗╂棤搴旂瓟鐨勬櫄鏈熼粦鑹茬礌鐦ゆ偅鑰呫€傜劧鑰岋紝鏁版湀涔嬪悗锛岄粯鍏嬪叕鍙哥殑Keytruda鑾峰緱FDA鎵瑰噯銆備粠姝わ紝杩欎袱绉嶈嵂鐗╀究浜х敓婵€鐑堢殑绔炰簤銆傝櫧鐒禟eytruda鍙兘浼氭垚涓篛pdivo閿€鍞笟缁╃殑缁婅剼鐭筹紝浣哋pdivo浠嶆槸鏈€浣崇殑鏂颁竴浠h偪鐦ゅ厤鐤不鐤楄嵂鐗┿€傜洰鍓嶅叾閫傚簲鐥囦粛鍦ㄦ墿澶э紝鍖呮嫭闈炲皬缁嗚優鑲虹檶鍜岃偩缁嗚優鐧屻€侀湇濂囬噾娣嬪反鐦ょ瓑銆傞璁?022骞寸殑骞撮攢鍞涓?26浜跨編鍏冦€侟/span>

3銆?/span>Imbruvica

鑹句集缁翠笌寮虹敓鍏卞悓寮€鍙戠殑BTK鎶戝埗鍓侷mbruvica(涓枃鍚嶏細渚濋瞾鏇垮凹)2013骞寸敱缇庡浗FDA鎵瑰噯锛屽彲鐢ㄤ簬濂楃粏鑳炴穻宸寸槫(MCL)鍜學aldenstr枚m宸ㄧ悆铔嬬櫧琛€鐥囩殑娌荤枟锛屽苟涓斿湪鎱㈡€ф穻宸寸粏鑳炵櫧琛€鐥?CLL)鐨勪簩绾垮競鍦轰腑澶勯鍏堝湴浣嶃€傞璁″埌2022骞撮攢鍞杈惧埌83浜跨編鍏冦€侟/span>

4銆?/span>Keytruda

褰撶劧锛屼綔涓篛pdivo瀵规墜鐨凨eytruda涔熶笉鏄蒋鏌垮瓙锛孠eytruda铏界劧鏄湪缇庡浗甯傚満鎶曟斁鐨勯涓狿D-1/PD-L1鎶戝埗鍓傦紝鐒惰€岄攢閲忓嵈涓嶅強Opdivo銆侹eytruda涓嶰pdivo鍦ㄩ粦鑹茬礌鐦わ紝闈炲皬缁嗚優鑲虹檶鍜屽ご棰堢檶涓繚鎸佺潃鐩存帴绔炰簤锛岀劧鑰岋紝瀹冭幏寰桭DA鎵瑰噯鐢ㄤ簬涓€绾縉SCLC娌荤枟鑰孫pdivo鍗存病鏈夛紝涔熻杩欎釜缁撴灉浼氬湪鏈潵鍑犲勾鍙嶈浆銆備笌Opdivo涓€鏍凤紝Keytruda姝f墿澶ч€傚簲鐥囷紝鍖呮嫭澶氬彂鎬ч楂撶槫锛岄湇濂囬噾娣嬪反鐦ゅ拰涔宠吅鐧岋紝浠ュ強鐮旂┒鑽墿鍦ㄧ粍鍚堢枟娉曚腑鐨勪綔鐢紝杩欐槸鑲跨槫鍏嶇柅娌荤枟鑽墿鐪熸鑳藉ぇ鏄捐韩鎵嬬殑鍦版柟銆傞鏈烱eytruda鍦?022骞寸殑閿€鍞浼氭湁鏈?5浜跨編鍏冦€侟/span>

5銆?/span>Ibrance

杈夌憺鍏徃鐨処brance鏄涓柊鍨婥DK4/6鎶戝埗鍓傦紝浜?015骞寸敱缇庡浗FDA鎵瑰噯涓婂競銆侰DK4/6鏄粏鑳炲懆鏈熺殑鍏抽敭璋冭妭鍥犵礌锛屽叾鑳藉瑙﹀彂缁嗚優鍛ㄦ湡杩涘睍銆傜敤涓庢潵鏇插攽鑱旂敤涓哄彲鐢ㄤ簬婵€绱犲彈浣撻槼鎬?HR+)銆佷汉琛ㄧ毊鐢熼暱鍥犲瓙鍙椾綋2-闃存€?HER2-)缁濈粡鍚庢櫄鏈熶钩鑵虹檶銆傝鑽墿鍦?016骞撮攢鍞杩呴€熶笂鍗囷紝鍦ㄤ笂鍗婂勾閿€鍞灏辨帴杩?.5浜跨編鍏冦€傞璁?022骞撮攢鍞涓?0浜跨編鍏冦€侟/span>

6銆?/span>Tecentriq

缃楁皬鍏徃鐨凾ecentriq鏄疨D-1/PD-L1鎶戝埗鍓傦紝骞跺湪鍏嶇柅娌荤枟鑽墿涓帓鍚嶇涓夈€?016骞?鏈堬紝缇庡浗FDA鍔犻€熸壒鍑員ecentriq鐢ㄤ簬娌荤枟鏈€甯歌绫诲瀷鐨勮唨鑳辩檶銆傝唨鑳辩檶(BC)鏄叏鐞冪9澶ф渶甯歌鐧岀棁锛岀敺鎬у彂鐥呯巼涓哄コ鎬?鍊嶃€傝繖灏变娇Tecentriq鏈夊箍闃旂殑甯傚満鍓嶆櫙锛屽悓鏃剁綏姘忎篃鍦ㄦ墿灞曡鑽殑鍙︿竴涓€傚簲鐥団€斺€旈潪灏忕粏鑳炶偤鐧屻€傞璁?022骞村皢鏈?5.3浜跨編鍏冪殑閿€鍞銆侟/span>

7銆?/span>Darzalex

2015骞?1鏈堬紝寮虹敓鍏徃Darzalex娉ㄥ皠娑茶幏寰楃編鍥紽DA鍔犻€熸壒鍑嗐€侱arzalex鐢ㄤ簬娌荤枟鏃㈠線鎺ュ彈杩囪嚦灏戜笁绉嶆不鐤楃殑澶氬彂鎬ч楂撶槫鎮h€呫€侱arzalex鏄涓幏鎵圭敤浜庢不鐤楀鍙戞€ч楂撶槫鐨勫崟鍏嬮殕鎶椾綋娉ㄥ皠娑层€傚鍙戞€ч楂撶槫鏄竴绉嶈娑茬檶鐥囷紝鍦ㄧ編鍥芥瘡骞村ぇ绾︽湁1涓囦汉姝讳簬澶氬彂鎬ч楂撶槫銆傜敱浜嶥arzalex鐨勫嚭鑹茶〃鐜帮紝FDA鎺堜簣浜咲arzalex绐佺牬鎬х枟娉曡瀹氥€佷紭鍏堝鎵硅祫鏍煎拰瀛ゅ効鑽瀹氥€傞璁?022骞达紝Darzalex娉ㄥ皠娑茬殑閿€鍞涓?9.1浜跨編鍏冦€侟/span>

8銆?/span>Perjeta

缃楁皬鐨凱erjeta浜?012骞寸涓€娆′笂甯傦紝鍦?013骞村彈缇庡浗FDA鐨勬壒鍑嗐€傝鑽墿涓庤但璧涙眬鎴栧瑗跨传鏉夐唶鍖栫枟涓€璧风敤浣滃弻閲嶆柟妗堜互鍑忓皯涔宠吅鐧岀殑浣撶Н銆傝鑽墿涔熸槸鎴愪负FDA鎵瑰噯鐨勯渚嬬敱鑲跨槫缂╁皬鑰屼笉鏄敓瀛樻暟鎹殑鍏堜緥銆傞璁?022骞寸殑閿€鍞涓?7.3浜跨編鍏冦€侟/span>

9銆?/span>Xtandi

Xtandi鏄緣鐟炲叕鍙歌姳璐?40浜跨編鍏冩敹璐璏edivation鍏徃锛屼粠鑰屽緱鍒版不鐤楀墠鍒楄吅鐧岃嵂鐗tandi銆俋tandi鏄柊鍨嬬殑闆勬縺绱犲彈浣撲俊鍙蜂紶瀵兼姂鍒跺墏锛屾瘡澶╁彲浠ュ彛鏈嶄竴娆°€傝鑽墿鑳藉闄嶄綆鐧岀粏鑳炵殑鐢熼暱锛屽苟鑳借瀵艰偪鐦ょ粏鑳炴浜°€?014骞?鏈堬紝缇庡浗FDA鎵瑰噯Xtandi鐢ㄤ簬鍓嶅垪鑵虹檶鍖栫枟鍓嶆不鐤楋紝闅忓悗锛孹tandi鍦ㄦ鐩熶笂甯傘€傜敱浜嶺tandi鐨勭敤鑽紭鍔垮拰鑹ソ鐨勬不鐤楁晥鏋滐紝浠庤€屽叿鏈夊箍闃旂殑甯傚満绌洪棿銆傞璁?022骞达紝璇ヨ嵂鐨勯攢鍞殑涓?7.1浜跨編鍏冦€侟/span>

10銆?/span>Avastin

缃楁皬鍏徃鐨勮礉浼愮彔鍗曟姉(Bevacizumab锛屽晢鍝佸悕锛欰vastin)2004骞磋幏寰桭DA鐨勬壒鍑嗭紝鏄編鍥介涓幏寰楁壒鍑嗕笂甯傜殑鎶戝埗鑲跨槫琛€绠$敓鎴愮殑鑽墿锛屾槸娌荤枟缁撹偁鐧岀殑涓€绾胯嵂鐗╋紝2010骞?鏈堝湪涓浗鑾峰緱鎵瑰噯锛岃仈鍚堜互5-姘熷翱鍢у暥涓哄熀纭€鐨勫寲鐤楅€傜敤浜庤浆绉绘€х粨鑲犵洿鑲犵檶鐨勬不鐤椼€傛渶杩戣幏寰楁娲茶鍙瘉锛岀敤浜嶦GFR闃虫€ч潪灏忕粏鑳炶偤鐧屾偅鑰呫€傞璁?022骞村叾閿€鍞涓?6.8浜跨編鍏冦€侟/span>


鏈枃鏉ユ簮浜庤嵂娓狘/span>

椴佸崡鍒惰嵂闆嗗洟
闃呰 87.9涓
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鍠滄姝ゅ唴瀹圭殑浜鸿繕鍠滄